diff --git a/CMakeLists.txt b/CMakeLists.txt
index cd3e576d9..441ad607e 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -67,7 +67,17 @@ add_definitions ( "/D_CRT_NONSTDC_NO_WARNINGS")
 add_definitions( "/wd4503")
 endif()
 
-SET(DFHACK_BUILD_ARCH "32" CACHE STRING "Architecture to build ('32' or '64')")
+# Automatically detect architecture based on Visual Studio generator
+IF(MSVC AND NOT DEFINED DFHACK_BUILD_ARCH)
+    IF(${CMAKE_GENERATOR} MATCHES "Win64")
+        SET(DFHACK_BUILD_ARCH "64")
+    ELSE()
+        SET(DFHACK_BUILD_ARCH "32")
+    ENDIF()
+ELSE()
+    SET(DFHACK_BUILD_ARCH "32" CACHE STRING "Architecture to build ('32' or '64')")
+ENDIF()
+
 IF("${DFHACK_BUILD_ARCH}" STREQUAL "32")
   SET(DFHACK_BUILD_32 1)
   SET(DFHACK_BUILD_64 0)
diff --git a/depends/protobuf/CMakeLists.txt b/depends/protobuf/CMakeLists.txt
index 085af746f..5b54c8335 100644
--- a/depends/protobuf/CMakeLists.txt
+++ b/depends/protobuf/CMakeLists.txt
@@ -202,6 +202,9 @@ LIST(APPEND LIBPROTOBUF_FULL_SRCS ${LIBPROTOBUF_LITE_SRCS})
 IF(CMAKE_COMPILER_IS_GNUCC)
     SET(CMAKE_CXX_FLAGS_RELWITHDEBINFO "${CMAKE_CXX_FLAGS_RELWITHDEBINFO} -Wno-sign-compare")
     SET(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -Wno-unused-result")
+ELSEIF(MSVC)
+    # Disable warnings for integer conversion to smaller type
+    SET(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} /wd4267")
 ENDIF()
 
 INCLUDE_DIRECTORIES(${CMAKE_CURRENT_SOURCE_DIR})
diff --git a/library/LuaApi.cpp b/library/LuaApi.cpp
index 387ac4d97..df077ccc1 100644
--- a/library/LuaApi.cpp
+++ b/library/LuaApi.cpp
@@ -2373,7 +2373,7 @@ static int internal_setAddress(lua_State *L)
 
     // Print via printerr, so that it is definitely logged to stderr.log.
     uintptr_t iaddr = addr - Core::getInstance().vinfo->getRebaseDelta();
-    fprintf(stderr, "Setting global '%s' to %x (%x)\n", name.c_str(), addr, iaddr);
+    fprintf(stderr, "Setting global '%s' to %p (%p)\n", name.c_str(), (void*)addr, (void*)iaddr);
     fflush(stderr);
 
     return 1;
diff --git a/library/VTableInterpose.cpp b/library/VTableInterpose.cpp
index 96cbfff9c..c547800c2 100644
--- a/library/VTableInterpose.cpp
+++ b/library/VTableInterpose.cpp
@@ -309,7 +309,7 @@ VMethodInterposeLinkBase::VMethodInterposeLinkBase(virtual_identity *host, int v
          */
 
         fprintf(stderr, "Bad VMethodInterposeLinkBase arguments: %d %p (%s)\n",
-                vmethod_idx, uintptr_t(interpose_method), name_str);
+                vmethod_idx, interpose_method, name_str);
         fflush(stderr);
         abort();
     }
diff --git a/plugins/ruby/ruby.cpp b/plugins/ruby/ruby.cpp
index adc451a19..127a49b69 100644
--- a/plugins/ruby/ruby.cpp
+++ b/plugins/ruby/ruby.cpp
@@ -1023,7 +1023,7 @@ static VALUE rb_dfmemory_set_clear(VALUE self, VALUE set)
 
 
 /* call an arbitrary object virtual method */
-#ifdef WIN32
+#if defined(_WIN32) && !defined(_WIN64)
 __declspec(naked) static int raw_vcall(void *that, void *fptr, unsigned long a0,
         unsigned long a1, unsigned long a2, unsigned long a3, unsigned long a4, unsigned long a5)
 {