diff --git a/plugins/tweak/tweak.cpp b/plugins/tweak/tweak.cpp
index 49d96cc74..13e08f174 100644
--- a/plugins/tweak/tweak.cpp
+++ b/plugins/tweak/tweak.cpp
@@ -59,6 +59,7 @@
 #include "df/reaction.h"
 #include "df/reaction_reagent_itemst.h"
 #include "df/reaction_reagent_flags.h"
+#include "df/reaction_product_itemst.h"
 #include "df/viewscreen_setupdwarfgamest.h"
 #include "df/viewscreen_layer_assigntradest.h"
 #include "df/viewscreen_tradegoodsst.h"
@@ -106,6 +107,7 @@
 #include "tweaks/stone-status-all.h"
 #include "tweaks/title-start-rename.h"
 #include "tweaks/tradereq-pet-gender.h"
+#include "tweaks/reaction-gloves.h"
 
 using std::set;
 using std::vector;
@@ -250,6 +252,8 @@ DFhackCExport command_result plugin_init (color_ostream &out, std::vector <Plugi
         "    Adds a safe rename option to the title screen \"Start Playing\" menu\n"
         "  tweak tradereq-pet-gender [disable]\n"
         "    Displays the gender of pets in the trade request list\n"
+        "  tweak reaction-gloves [disable]\n"
+        "    Changes custom reactions to produce gloves in sets with correct handedness\n"
 //        "  tweak military-training [disable]\n"
 //        "    Speed up melee squad training, removing inverse dependency on unit count.\n"
     ));
@@ -332,6 +336,8 @@ DFhackCExport command_result plugin_init (color_ostream &out, std::vector <Plugi
 
     TWEAK_HOOK("tradereq-pet-gender", pet_gender_hook, render);
 
+    TWEAK_HOOK("reaction-gloves", reaction_gloves_hook, produce);
+
     return CR_OK;
 }
 
diff --git a/plugins/tweak/tweaks/reaction-gloves.h b/plugins/tweak/tweaks/reaction-gloves.h
new file mode 100644
index 000000000..6ef3c6ccf
--- /dev/null
+++ b/plugins/tweak/tweaks/reaction-gloves.h
@@ -0,0 +1,75 @@
+// Workaround for DF bug #6273 - adjust all custom reactions to produce GLOVES items in sets with correct handedness
+// It also analyzes the body plan of the unit performing the reaction, so Antmen will get 4 gloves instead of 2
+
+// If a reaction tries to produce either 1 glove or 2 gloves, it will produce a single set
+// Otherwise, it will multiply the number of products by the number of hands
+
+struct reaction_gloves_hook : df::reaction_product_itemst {
+    typedef df::reaction_product_itemst interpose_base;
+
+    DEFINE_VMETHOD_INTERPOSE(void, produce, (df::unit *unit, std::vector<df::reaction_product*> *out_products, std::vector<df::item*> *out_items, std::vector<df::reaction_reagent*> *in_reag, std::vector<df::item*> *in_items, int32_t quantity, df::job_skill skill, df::historical_entity *entity, int32_t unk_1, df::world_site *site, void *unk_2))
+    {
+        if (item_type != df::item_type::GLOVES)
+        {
+            INTERPOSE_NEXT(produce)(unit, out_products, out_items, in_reag, in_items, quantity, skill, entity, unk_1, site, unk_2);
+            return;
+        }
+
+        // Examine creator unit's body plan, see how many hands it has
+        // Count left hands and right hands, as well as "neutral" hands for compatibility
+        int num_hands = 0, num_left = 0, num_right = 0;
+        for (int i = 0; i < unit->body.body_plan->body_parts.size(); i++)
+        {
+            df::body_part_raw *part = unit->body.body_plan->body_parts[i];
+            if (part->flags.is_set(df::body_part_raw_flags::GRASP))
+            {
+                num_hands++;
+                if (part->flags.is_set(df::body_part_raw_flags::LEFT))
+                    num_left++;
+                if (part->flags.is_set(df::body_part_raw_flags::RIGHT))
+                    num_right++;
+            }
+        }
+
+        std::vector<df::item*> out_items_temp;
+        int old_count = count;
+
+        // If the reaction product's count is set to 1 or 2, set it to the number of hands
+        // Otherwise, *multiply* it by the number of hands (and multiply the left/right counts accordingly)
+        if (count <= 2)
+            count = num_hands;
+        else
+        {
+            num_left *= count;
+            num_right *= count;
+            count *= num_hands;
+        }
+
+        INTERPOSE_NEXT(produce)(unit, out_products, &out_items_temp, in_reag, in_items, quantity, skill, entity, unk_1, site, unk_2);
+        count = old_count;
+
+        // If the reaction was somehow asked to produce multiple sets (due to excess inputs), multiply the outputs too
+        num_left *= quantity;
+        num_right *= quantity;
+
+        // Iterate across the output gloves, set their handedness, then append them to the actual out_items list for DF
+        for (int i = 0; i < out_items_temp.size(); i++)
+        {
+            // Do left gloves first, then right gloves, then "neutral" ones last
+            // This is important for the "createitem" plugin, which contains similar workaround logic
+            if (num_left > 0)
+            {
+                out_items_temp[i]->setGloveHandedness(1);
+                --num_left;
+            }
+            else if (num_right > 0)
+            {
+                out_items_temp[i]->setGloveHandedness(2);
+                --num_right;
+            }
+            out_items->push_back(out_items_temp[i]);
+        }
+    }
+};
+
+IMPLEMENT_VMETHOD_INTERPOSE(reaction_gloves_hook, produce);
\ No newline at end of file